The Scaliger Family Papers, when taken together, trace the history of a noble family that was originally from Italy but lived primarily in Agen, France from the mid-1500s through the mid-1800s. Beginning with the patriarch, Julius Caesar Scaliger (1484-1558), a celebrated Italian scholar and physician, the members of the Scaliger family upheld an illustrious reputation over the centuries as scholars, military leaders, and noblemen. Throughout their family's history, the Scaligers maintained that they were descended from the Della Scallas, Princes of Verona. It is as a result of the necessity to defend this claim as well as later attempts to prove their ties to their noble heritage that this collection of documents has remained so well intact. The Scaliger Family Papers is a collection that encompasses several different kinds of documents that span from 1539 to 1862 including letters, genealogical material, works by members of the Scaliger family, as well as military, legal, and financial documents.

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.